Baseline genomic landscape in paired purified B-cell DNA and ctDNA detected in plasma. (A) The heat map illustrates the paired analysis of purified CLL cells DNA (orange), ctDNA (light blue), and the shared mutations between B cells and ctDNA compartments (red). Each column represents a sample, and genes/copy number abnormalities (CNAs) are represented in rows. Venn diagrams summarizing the overall number of mutations (B) and CNAs (C) discovered only in B-cellular DNA (orange), only in plasma ctDNA (light blue), or in both plasma ctDNA and B-cellular DNA (red). Dia PL, plasma ctDNA at diagnosis.