Figure 7.
Impact of TG2 deficiency on APAP-induced liver injury. Male wild-type and TG2−/− mice were challenged with 300 mg/kg APAP and plasma, and liver samples were collected 24 hours later. Plasma alanine aminotransferase (ALT) activity (A), area of hepatocellular necrosis (B), and hepatic congestion/hemorrhage (C) were determined as described in “Materials and methods.” (D) Representative photomicrographs of hematoxylin and eosin–stained paraffin-embedded liver tissues (20× virtual objective). Arrowheads indicate areas of congestion/hemorrhage. The dashed box depicts the approximate location of the higher-magnification image below. Results from individual mice are plotted and bars represent mean ± SEM. ∗P < .05. Scalebar (200 microns); scalebar for inset (20 microns).

Impact of TG2 deficiency on APAP-induced liver injury. Male wild-type and TG2−/− mice were challenged with 300 mg/kg APAP and plasma, and liver samples were collected 24 hours later. Plasma alanine aminotransferase (ALT) activity (A), area of hepatocellular necrosis (B), and hepatic congestion/hemorrhage (C) were determined as described in “Materials and methods.” (D) Representative photomicrographs of hematoxylin and eosin–stained paraffin-embedded liver tissues (20× virtual objective). Arrowheads indicate areas of congestion/hemorrhage. The dashed box depicts the approximate location of the higher-magnification image below. Results from individual mice are plotted and bars represent mean ± SEM. ∗P < .05. Scalebar (200 microns); scalebar for inset (20 microns).

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