Figure 7.
CIMP percentage association with DNA methyltransferase gene expression, chronological and cellular age in the NOPHO ALL2008 cohort. Correlation of CIMP methylation percentage and (A) DNA methyltransferase 3 alpha (DNMT3A) and (B) beta (DNMT3B) gene expression (in VST counts) in 108 T-ALL patient samples and 3 control cells (CD34+, CD3+, and lymph node). Correlation of CIMP methylation percentage and (C) chronological age of peripheral blood leukocytes in healthy children (n = 78, aged 1-16 years) and diagnostic T-ALL patient samples (n = 192). (D) Horvath biological age and (E) EpiTOC mitotic clock. Spearman correlation rho and P values were estimated among T-ALL samples only, not including healthy samples. CIMP percentage is defined as the percentage of CIMP panel CpGs with a β-value >0.4.

CIMP percentage association with DNA methyltransferase gene expression, chronological and cellular age in the NOPHO ALL2008 cohort. Correlation of CIMP methylation percentage and (A) DNA methyltransferase 3 alpha (DNMT3A) and (B) beta (DNMT3B) gene expression (in VST counts) in 108 T-ALL patient samples and 3 control cells (CD34+, CD3+, and lymph node). Correlation of CIMP methylation percentage and (C) chronological age of peripheral blood leukocytes in healthy children (n = 78, aged 1-16 years) and diagnostic T-ALL patient samples (n = 192). (D) Horvath biological age and (E) EpiTOC mitotic clock. Spearman correlation rho and P values were estimated among T-ALL samples only, not including healthy samples. CIMP percentage is defined as the percentage of CIMP panel CpGs with a β-value >0.4.

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