CIMP, MRD 0.1%, and relapse in the study of NOPHO ALL2008 and validation DCOG ALL-10/ALL-11 cohorts. Proportion of outcomes in 172 NOPHO (A) and 137 DCOG (D) pediatric patients with T-ALL; outcomes were relapse (n = 23/n = 18), DCR (n = 12/n = 8), SMN (n = 2/n = 1), and nonresponders (n = NA/n = 1) with CR (n = 135/n = 109) as reference, respectively. Samples were stratified by CIMP and MRD at D29/D33 MRD combined subgroups and (B,E) corresponding risk of relapse tables. Forest plots reveal the accuracy (estimated as [true positives + true negatives]/total) of D15 MRD and D29/D33 MRD above 0.1/0.01% cutoffs and CIMP-low status, alone or in combination, for differentiating relapse from CR in (C) the NOPHO and (F) the DCOG cohorts. NA, not available.