TM domain structure and positions of the investigated variants. The individual protein domains are indicated. The 8 missense variants identified in patients with bleeding (red) or venous thrombosis (blue) are annotated using the single-letter amino acid code. The detected functional alterations of the C175S and L433P variants are summarized on the right-hand side. ∗Effect only significant for the soluble mutant. Adapted from Figure 1 in the article by Van Laer et al that begins on page 1929.