Figure 1.
![Histopathologic features of HSTCL. (A) Splenic biopsy shows diffuse sinusoidal infiltrates of atypical lymphocytes of variable size with loosely condensed nuclear chromatin and inconspicuous nucleoli (hematoxylin and eosin [H&E] stain; image original magnification, 40×). (B) Bone marrow biopsy shows relative hypercellularity with dilated sinuses containing bland-appearing small lymphocytes (H&E stain; image original magnification 40×). (C) Malignant cells usually stain positive for T-cell markers, including CD3 (H&E stain; image original magnification 40×). (D) Most express TCR γδ (H&E stain; image original magnification 40×). The most common cytogenetic abnormality in HSTCL is isochromosome 7 (E), followed by trisomy 8 (F).](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/9/8/10.1182_bloodadvances.2025015857/2/blooda_adv-2025-015857-gr1.jpeg?Expires=1748492839&Signature=lTnXKmQGPlREsGMFyWPBXdrfXbCm2jqRWHLigGkTZgXPS9uxPi3R4m1p65L-nFdYxAM5W2UMUFL9ON4yT7bBhwuEMMSJMyMjckZPyopC8kG11bzomIbmZW0eL-IpGxkxbJKbWBf1aeR~-qcPjinm8Lkm4mTROQaCFRefYmWErYZq88W3e-cS~oiKhRCOO~bqJhWCe5eJ2Hn3N1vGWjOCwqbU3GVr4R15kWXtA33cYWMO9hsXfpwcKycWSXlchTlkHj6dK1mNlLDHpVh4vkukthixIhF6sNF-Vh9EmHA-zoZdohXgtqnX3jhKlp~gXL9IFVnT-wkRKBPPjjWFoqC6wg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Histopathologic features of HSTCL. (A) Splenic biopsy shows diffuse sinusoidal infiltrates of atypical lymphocytes of variable size with loosely condensed nuclear chromatin and inconspicuous nucleoli (hematoxylin and eosin [H&E] stain; image original magnification, 40×). (B) Bone marrow biopsy shows relative hypercellularity with dilated sinuses containing bland-appearing small lymphocytes (H&E stain; image original magnification 40×). (C) Malignant cells usually stain positive for T-cell markers, including CD3 (H&E stain; image original magnification 40×). (D) Most express TCR γδ (H&E stain; image original magnification 40×). The most common cytogenetic abnormality in HSTCL is isochromosome 7 (E), followed by trisomy 8 (F).
