Mutation landscape of individual responses to DDAVP. Each dot represents a patient. Colors represent no (dark red), partial (red), and complete (light red) response. Missense mutation position relative to the protein sequence are plotted on the x-axis against response. (A) Variants in HA; y-axis represents peak FVIII:C levels after DDAVP. (B) Variants in VWD; y-axis represents peak VWF:Ag levels after DDAVP. Shape depicts VWD type 1 (circle) and type 2 (triangle). Protein domains and relevant annotations are plotted at the top of each graph.