Complete response rate varies per disease subtype according to the study definition. (A) Number of patients per disease type included in the meta-analysis. Disease types with <3 articles are excluded from this analysis. (B) Meta-analysis on response to DDAVP at 1 hour in patients with different bleeding disorders per subtype according to the study definition. Using a random effect model, the proportions of complete response per disease type are shown. The proportion of response is not 0 in zero-event studies due to the continuity correction that was performed to prevent mathematical errors. (C) Response to DDAVP of patients with VWD type 1 and VWD types 2A, 2B, and 2M. In the top panel, VWF:Ag (U/dL) before (light red) and after 1 hour of DDAVP (dark red) are shown. In the bottom panel, VWF:Act (U/dL) is shown. VWD type 2N is not displayed in this figure because only 2 studies had data on both VWF:Ag and VWF:Act.