Göbel et al defined that EZH2 and DOT1L cooperate to repress PRC2 target genes and support the proproliferative GC B-cell state in DLBCL. Dual inhibition of EZH2 and DOT1L represents a differentiation-based therapeutic strategy to target GCB DLBCL.
Göbel et al defined that EZH2 and DOT1L cooperate to repress PRC2 target genes and support the proproliferative GC B-cell state in DLBCL. Dual inhibition of EZH2 and DOT1L represents a differentiation-based therapeutic strategy to target GCB DLBCL.
