Overview of hematologic markers and correlations with fatigue. (A) Least squares mean change from baseline in Hb level, LDH, and FACIT-Fatigue score during the 168-day core treatment period of APPLY-PNH^a,b. (B) Correlation of Hb, LDH, and FACIT-Fatigue at day 168 of APPLY-PNH. (C) Least squares mean change from baseline in Hb level, LDH, and FACIT-Fatigue scores during the 168-day core treatment period of APPOINT-PNH^a,b. (D) Correlation of Hb, LDH, and FACIT-Fatigue at baseline and day 168 of APPOINT-PNH. Bas, baseline; bid, twice daily; C5i, C5 inhibitor; FACIT-Fatigue, Function Assessment of Chronic Illness–Fatigue; Hb, hemoglobin; LDH, lactate dehydrogenase; RBC, red blood cell; ULN, upper limit of normal. ^a Change from baseline in Hb level does not include data within 30 days of RBC transfusion. Change from baseline in FACIT-Fatigue score and LDH includes data from patients who received RBC transfusion. ^b Error bars represent 95% confidence intervals.