The predictive value of C3 in the progression from partial HLH to HLH. (A) Distribution of different triggers in partial HLH and HLH groups. The HLH group mainly triggered by infection and malignancy. (B) C3 was significantly lower in the HLH group than the partial HLH group. (C) The ROC curve of C3 for discriminating partial HLH and HLH. (D) The forest plot of univariate and multivariate logistic regression analysis. (E) In different triggers, C3 was significantly lower in the HLH group than the partial HLH group. ∗∗∗P < .001; ∗∗∗∗P < .0001; ns, nonsignificance. AUC, area under the ROC curve; 95% CI, 95% confidence interval; ALT, alanine aminotransferase; BUN, blood urea nitrogen; HM, hematologic malignancy; LDH, lactate dehydrogenase; Tbil, total bilirubin.