Csf3r mutation induces an aberrant neutrophil phenotype. (A) Comparison of peripheral blood cell counts between 8 weeks and 92 weeks post-Cre induction of female mice (mean ± SEM; n = 9-12 per group). Significance was evaluated with a mixed-effect analysis with Sidak multiple comparison test. (B) Quantification of white blood cells in peripheral blood smears of mice 1 year after Cre induction (mean ± SEM; n = 2 per group in duplicate). Significance was evaluated with a 2-way ANOVA with Tukey multiple comparison test. (C) Peripheral blood neutrophil counts of female mice in 92 weeks. Dotted lines represent normal count limits as described by the Charles River Laboratories for C57BL/6 mice in their North American Colonies for mice aged 8 to 10 weeks. (D) Survival of female mice from each genotype is illustrated in a Kaplan-Meier plot. No significance was found by the Mantel-Cox test. ∗P < .05, ∗∗P < .01, ∗∗∗P < .001, ∗∗∗∗P < .0001.