Neutrophils, neutrophil trafficking markers, and microbiome diversity during induction treatment. ANC (A), CXCL1 plasma levels (B), CXCL8 plasma levels (C), G-CSF plasma levels (D), and gut microbiota α-diversity (E) in all patients. (F-J) grouped by neutropenia status (ANC <0.5 × 109 cells per L) at day 36. Patients with neutropenia on day 36 had significantly higher levels of CXCL1, CXCL8, and G-CSF throughout the induction period (no interaction with the time point) and lower α-diversity on day 1. Boxes show the median levels with 25th and 75th percentiles. Asterisks represent differences between day 8 levels (B-D), day 1 levels (E), and comparisons between groups (G-J). P values correspond to generalized linear mixed models without interaction between time points for panels G-I. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001.
