Prognostic impact of ctDNA levels and molecular clusters. Kaplan-Meier estimates of (A) PFS and (B) OS according to ctDNA levels. Patients with ctDNA levels of <2.5 log₁₀ hGE/mL are represented by the blue curve and patients with ctDNA levels of ≥2.5 log₁₀ hGE/mL are represented by the red curve. (C) Recursive partitioning plot according to ctDNA levels and assignment to clusters ST2/BN2. Kaplan-Meier estimates of (D) PFS and (E) OS in patients with ctDNA levels of ≥2.5 log₁₀ hGE/mL according to ST2/BN2 molecular clusters. Patients assigned to ST2/BN2 are represented by the blue curve. Patients not assigned to ST2/BN2 are represented by the red curve.