Hypoxia-induced increase in RVSPs was similar in WT and Nbeal2^−/− mice; hypoxia-induced RVH was delayed in Nbeal2^−/− mice. (A) RVSP increased in hypoxic WT and Nbeal2^−/− mice at days 21 and 35. At day 21, the hypoxia-induced elevation in RVSP was increased in Nbeal2^−/− compared with WT mice. (B) At day 21, hypoxia-induced RVH was prevented in Nbeal2^−/− mice. At day 35, hypoxia-induced RVH was similar between WT and Nbeal2^−/− mice. Statistics: P ≤.05 by 2-way ANOVA with Tukey post hoc analysis. Comparisons: (∗) WT compared with WT baseline, (#) Nbeal2^−/− compared with Nbeal2^−/− baseline, (^) WT compared with Nbeal2^−/−. NMX, normoxia.