Genetic Acly ablation prevents PTEN loss–induced T-ALL/lymphoma development. (A) Kaplan-Meier survival curve for PTENΔ/Δ mutant mice (n = 43), ACLY Δ/Δ mutant (n = 16), PTENΔ/Δ;ACLY Δ/Δ double-mutant mice (n = 22), and floxed controls (n = 40). (B-C) TCRβ rearrangements (B) and phenotypic analysis of the thymus (C) in PTENΔ/Δ mutant, ACLYΔ/Δ mutant, PTENΔ/Δ;ACLYΔ/Δ animals, or flox controls. (D-F) CD4⁺ absolute numbers cells in the spleen (D), bone marrow (E), and lymph nodes (F) in 14-week-old PTENΔ/Δ mutant, ACLYΔ/Δ mutant, PTENΔ/Δ;ACLYΔ/Δ animals, or flox controls (including Ptenflox2, Aclyflox2 and Ptenflox2;Aclyflox2 mice). BM, bone marrow.