Figure 2.
Global inflammatory and organ-specific transcriptomic signatures of the HbSS mice compared with HbAA. Volcano plots of the signature in the liver (A), heart (B), kidney (C), lung (D), and BM (E). The red dots represent the upregulated and downregulated genes in HbSS mice compared with HbAA (adjusted P < .5; log2 FC less than or equal to −1 or ≥1). (F) GSEA of the gene sets affected in the 5 organs. The heat map is built to represent the z score for each pathway, which is calculated as the NES multiplied by the −log10 q value, which is the P value adjusted for FDR. The Hallmarks pathways are grouped manually depending on the overall biological processes to which they can be related. (G) Upstream pathways, responsible for the transcriptomic changes in the tested organs, estimated by ingenuity pathways. AGT, angiotensin; BM, bone marrow; FC, fold change; NS, not significant.

Global inflammatory and organ-specific transcriptomic signatures of the HbSS mice compared with HbAA. Volcano plots of the signature in the liver (A), heart (B), kidney (C), lung (D), and BM (E). The red dots represent the upregulated and downregulated genes in HbSS mice compared with HbAA (adjusted P < .5; log2 FC less than or equal to −1 or ≥1). (F) GSEA of the gene sets affected in the 5 organs. The heat map is built to represent the z score for each pathway, which is calculated as the NES multiplied by the −log10 q value, which is the P value adjusted for FDR. The Hallmarks pathways are grouped manually depending on the overall biological processes to which they can be related. (G) Upstream pathways, responsible for the transcriptomic changes in the tested organs, estimated by ingenuity pathways. AGT, angiotensin; BM, bone marrow; FC, fold change; NS, not significant.

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