Alteration of organ functions in HbSS vs HbAA mice. (A) Representation of Townes genotypes. (B) Quantification of (from left to right) Hb, hematocrit, MCHC, MCV, and platelets in the blood of HbAA (blue) and HbSS (red) mice. (C) Quantification of platelets in the blood of HbAA (blue) and HbSS (red) mice. (D) Quantification of (from left to right) leukocytes, lymphocytes, monocytes, granulocytes, and eosinophils of HbAA (blue) and HbSS (red) mice. (E) Quantification of ALAT (left) and ASAT (right) of HbAA (blue) and HbSS (red) mice. (F) Quantification of urea (left) and creatinine (right) in the blood of HbAA (blue) and HbSS (red) mice. (G) Quantification of CK (left) and protids (right) in the blood of HbAA (blue) and HbSS (red) mice. (H) Weight of total spleen (left) or total weight of HbAA (blue) and HbSS (red) mice. (I) Picture of HbAA and HbSS mice spleen. (J) Measurement of pH (left), partial pressure in CO₂ (pCO₂; middle left), partial pressure in O₂ (pO₂; middle), and bicarbonates concentration (right) in venous blood of HbAA (blue) and HbSS (red) mice. Hematological parameters in Townes HbAA and HbSS mice evaluated by blood counter (∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001; Mann-Whitney test). ALAT, alanine aminotransferase; ASAT, aspartate aminotransferase; CK, creatine kinase; MCHC, mean corpuscular Hb concentration; MCV, mean corpuscular volume; WT, wild type C57Bl/6 mouse as a negative control.