siRNA-mediated BCL2, CLIP2, and VAV3 knockdown increased ADE components’ sensitivity. (A) Results of MOLM-13 cell line, with bar plot (left) showing the effect of siRNA-mediated knockdown for each gene in relative messenger RNA expression compared with NTC. The viability inhibition curves for each ADE component (top); an siRNA-mediated knockdown confirmation quantitative polymerase chain reaction (qPCR) plot (left) for each gene interest compared with NTC, and IC50 values were calculated for each cell condition per drug plot. Bar plots (bottom) showing specific drug concentrations with cell viability (%) of siRNA in the gene of interest compared with NTC for each ADE component. (B) Results of ML-2. Data are presented as mean ± SD. Cell viability and qPCR experiments included 3 technical replicates for each sample condition. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001. Dauno, daunorubicin; Etop, etoposide.