Figure 2.
Biological pathway enrichment analysis with GSEA for each drug and ORA comparison among all drugs. (A) GSEA dot plot with Reactome biological pathway database for the whole gene set of CRISPR screens with decreasing ranking in diff-β scores for each drug. (B) Bar plots showed several significant genes that met each drug's 2 SD cutoff for resistant or sensitive genes. (C) ORA dot plot showed CRISPR significant gene comparing across 3 drugs; significant pathway gene sets have FDR <0.1; P value represents adjusted P value with FDR. FDR, false discovery rate; GPCR, G protein-coupled receptors; GTP, guanosine triphosphate; PpS, Peters plus syndrome; TSR, thrombospondin type 1 repeat; TPBS, temtamy preaxial brachydactyly syndrome; tRNA, transfer RNAs.

Biological pathway enrichment analysis with GSEA for each drug and ORA comparison among all drugs. (A) GSEA dot plot with Reactome biological pathway database for the whole gene set of CRISPR screens with decreasing ranking in diff-β scores for each drug. (B) Bar plots showed several significant genes that met each drug's 2 SD cutoff for resistant or sensitive genes. (C) ORA dot plot showed CRISPR significant gene comparing across 3 drugs; significant pathway gene sets have FDR <0.1; P value represents adjusted P value with FDR. FDR, false discovery rate; GPCR, G protein-coupled receptors; GTP, guanosine triphosphate; PpS, Peters plus syndrome; TSR, thrombospondin type 1 repeat; TPBS, temtamy preaxial brachydactyly syndrome; tRNA, transfer RNAs.

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