PLT activation and procoagulant potential in PwHAs and carriers in comparison with HCs. (A) PLT aggregation after adenosine 5′-diphosphate (ADP) (2 μM) stimulation is significantly reduced in PwHAs when compared with HCs. (B) No significant correlation between ADP (2 μM) response and ISTH-BAT bleeding scores. (C) No significant correlation between ADP (2 μM) response and ABR. (D) PCPs after thrombin (10 U/mL)/convulxin (CVX) (0.5 μg/mL) stimulation are significantly increased in PwHAs and carriers when compared with HCs. (E) Higher PCP percentages correlate negatively with ISTH-BAT bleeding score, indicating that increased PCP levels are associated with lower bleeding severity. (F) Higher PCP percentages correlate negatively with the ABR, suggesting that elevated PCP levels are linked to a reduced bleeding frequency. Each dot represents an individual patient categorized by hemophilia severity, categorized as severe (red), moderate (yellow), mild (green), carrier (white), and HC (blue).