Change from baseline in Haem-A-QoL domains.^∗A reduction of 7.1 points in “total score” is regarded as a clinically meaningful improvement and is depicted by the dashed line.^31 †A reduction of 10 points in “physical health” is regarded as a clinically meaningful improvement and is depicted by the dashed line.^31 ‡Last non-missing assessment on or before the first significant dose. ^§Under the original dose regimen the mean change in baseline was through 24 months (n = 14). ^ǁUnder the AT-based dose regimen the mean change from baseline was through 12 months (n = 9).