CBA and molecular evaluation of chromosomal mimicry in MGB-Mimicry-003 findings. Conventional cytogenetic studies (karyotyping and FISH) are shown on the left. Molecular confirmation with Hi-C is shown on the right. In the top panel, CBA and FISH studies detect a t(8;21)(q22;q22) with RUNX1::RUNX1 fusion by FISH. Hi-C notes rearrangements on chromosomes 8 and 21 that do not overlap with RUNX1 or RUNX1T1. In the bottom panel, CBA, FISH, and OGM is showing a positive control with a confirmed t(8;21) leading to RUNX1::RUNX1T1.