Low T-cell infiltration PBL signature PCNSL shows unfavorable prognosis. (A) Representative IHC images of 2 samples show tumor cells diffusely positive for CD20 and the variations in the infiltration of CD3⁺, CD8⁺, and CD68⁺ cells. Small panel of CD20 staining shows an overall image of the tumor. Scale bar shows 100 μm. (B) Kaplan-Meier survival curves of PFS (left) and OS (right) for patients with high or low CD3⁺ infiltration. (C) Kaplan-Meier survival curves of PFS (left) and OS (right) for patients with high or low CD8⁺ infiltration. (D) Kaplan-Meier survival curves of PFS (left) and OS (right) for patients with high or low CD68⁺ infiltration. (E) Kaplan-Meier survival curves show no significant difference in PFS (left) or OS (right) between patients with or without CD13⁺ lymphoma cells. Kaplan-Meier survival curves for PFS (F) and OS (G) according to the presence of CD138⁺ cells and the degree of CD3⁺ cell infiltration. The tables show adjusted P value using the Benjamini-Hochberg method, with P values <.05 highlighted in red.