AUC for prediction of significant or mild neurocognitive impairment using clinical characteristics and caregiver signaling questions. Performance of clinical characteristics and caregiver signaling questions as predictors of significant (>1.5 SD below the normative mean on ≥2 out of 6 measures) or mild (>1 SD below the normative mean on ≥2 out of 6 measures) neurocognitive impairment. The x-axes and y-axes indicate specificity (true negative rate) and sensitivity (true positive rate), respectively. Three models are presented in each figure. Model 1 (Clinical) included only clinical characteristics as predictors (patient age at the time of the evaluation, genotype, use of hydroxyurea before evaluation, social vulnerability). Model 2 (CRS) included only an aggregate CRS for a child’s history of grade retention, history of learning difficulties, or poor grades (Cs, Ds, Fs, variable). Model 3 (Clinical + CRS) included clinical characteristics and an aggregate CRS for a child’s history of grade retention, history of learning difficulties, or poor grades (Cs, Ds, Fs, variable). (A) Significant impairment defined as performance >1.5 SD below the normative mean on ≥2 out of 6 measures. (B) Mild impairment defined as performance >1 SD below the normative mean on ≥2 out of 6 measures.