3K3A-APC reduces postischemic injury areas in control mice but not in Arrb2^–/– mice. (A) Representative images of cresyl violet staining of brain sections 24 hours after tMCAo from control and Arrb2^–/– mice on a C57BL/6J genetic background treated with vehicle or 3K3A-APC as in Figure 1. Injury areas are delineated by yellow dashed lines. Mice used for representative images in panel A are the same as in Figure 2A. The tissue sections for cresyl violet staining were taken from the same locations relative to the bregma as for T2-weighted MR scans in Figure 2; scale bar, 5 mm. (B) Incidence and topography of injury area at the level of optic chiasm (ie, image for the bregma +1.0 mm) in control mice and Arrb2^–/– mice treated with vehicle or 3K3A-APC. Control + vehicle (n = 6); control + 3K3A-APC (n = 6); Arrb2^–/– + vehicle (n = 5); Arrb2^–/– + 3K3A-APC (n = 5).