T-cell clusters of significance. (A) p53 status identifies differential frequencies of immune populations derived from either BMMCs or PBMCs. BMMC and PBMC samples were segregated based on p53 genotype. (B) BMMC and PBMC samples were segregated based on response to therapy, CR, or no R. Cluster number is in the upper left of each plot. Eight clusters trended toward significance or were significant (∗P < .05 by t test; ∗∗P < .05 by t test with Bonferroni correction). CR, complete remission; DC, dendritic cells; mut, mutation; NK cell, natural killer cell; no R, no remission; wt, wild type.