iWM is associated with CH. Red represents patients with iWM; and blue, patients with noninflammatory WM (non-iWM). (A) CRP level at sequencing between patients with/without CH detected. The shape represents the type of CH mutation: triangle for DTA, square for the other one, and round for the absence of CH mutation detected. (B) Number of CH mutations detected based on the inflammatory status of patients with WM. (C) Type of CH mutation detected on multiple patients based on the inflammatory status of patients with WM. Genes with a mutation that occurred only once were CBL, SETBP1, RUNX1, NRAS, KRAS, and KDM6A. (D) VAF of each CH mutation detected in iWM and non-iWM. (E) The generalized linear model of CH presence is based on age, prior chemotherapy/radiotherapy exposure, type of sample, and inflammatory status of WM. (F) CRP level at sequencing based on CH mutation and del6q in WM (17 iWM and 24 non-iWM with follow-up). The size of points represents the VAF of CH mutations. The red number represents the proportion of iWM in each subcategory.