GSI alters predicted cell-cell interactions within the tumor microenvironment. (A-B) Bar plots showing the total number of significant interactions between pre- and post-GSI treatment samples. Only cell-cell interactions that significantly increased (Fisher exact test P < .05) (A) or decreased (B) after GSI treatment are shown. (C-D) Dot plot illustrating the average expression and interaction specificity of ligand-receptor pairs that significantly increased (C) or decreased (D) in frequency after GSI. Only interactions in which the ligand or receptor are recognized substrates of γ-secretase are shown (bold text).