F5-G/G group phenotype in UK Biobank. A Forest plot of the ORs for the first hospital episode of VTE (top row), bleeding (middle row), and cardiovascular disease (CVD, bottom row) among UKB participants who are F5-G/G (n = 8699) in comparison with participants who are either heterozygous for the G haplotype or homozygous for the reference sequence (n = 109 000). These clinical outcomes were determined using the HES (supplemental Methods). The circle represents the OR and the error bars the 95% confidence interval.