The CD3×CD3 BsAb is superior to steroids or cyclophosphamide in a xenogeneic mouse model of GVHD. (A) GVHD score of mice treated with dexamethasone (0.8 mg/mouse per dose), cyclophosphamide (1.25 mg/mouse per dose), or CD3×CD3 BsAb (10 μg/mouse per dose) IP twice per week for 2 weeks. (B) Weight change of the same animals plotted as percent change from starting day. (C) Survival of the same animals. Note that the 2 mice that were censored from the survival graph were euthanized because of neurological impairment (head tilt) attributed on necropsy to eye and ear infections. n = 5 mice per group. Gold asterisks indicate treatment days. Experiment was conducted once.