BCR and TCR repertoire diversity in the 2 patient sets. The frequencies of immunoglobulin heavy (H) and light (L) clonotypes are depicted for each sample, along with the contribution of TCR sequences. The samples were sorted based on the percentage of immunodominant clones (IgH + IgL dominant CDR3) and by cohort as follows: the PMBL LYSA cohort (5′RACE set) and the validation cohort. Samples with the HCD as defined by 5′RACE are indicated in red.