Description of the median VAF determined by NGS and clonal dominance assessed by 5′RACE in patients with available data for both variables (n = 67 in 5′RACE set). (A) Box plot displaying the median VAF comparison between patients with the HCD (n = 12) and others (n = 55). (B) Correlation between the degree of B-cell clonal dominance (defined by the percentage of CDR3 sequences occupied by the dominant clone) according to 5′RACE and the median VAF of somatic variants detected by NGS (5′RACE set).