Epigenetic and genetic characterization of the differential signature of the B-PLL epitypes. (A) Heat map of the de novo epitype 1 specific methylation signature (n = 799 CpGs). (B) Oncoplot showing genetic alterations of B-PLL cases. (C) Heateukemic nonnodal map of 97 differentially expressed genes between B-PLL epitypes. (D) Gene set enrichment analysis (GSEA) showing enrichment of MYC targets in epitype 1 B-PLL (E) MYC expression percentile of B-PLL, CLL, and MCL cases (F) Bar plot of the numbers of differentially methylated CpGs between CD5⁺ epitype 2 and CD5⁻ epitype 2 (top) and heat map of DM CpGs between CD5⁺ epitype 1 and CD5⁺ epitype 2 (n = 2014; bottom) (G) Kaplan-Meier curves for overall survival between B-PLL epitypes.