Differential DNA methylation patterns of B-PLL compared with CLL/PL and MCL P/B. (A) Heat map of the differentially methylated CpGs between B-PLL and CLL/PL (n = 3197). (B) PCA of the differentially methylated CpGs between B-PLL and CLL with <10% prolymphocytoid cells (n = 2906), including also the CLL/PL (showing the percentage of cells with prolymphocytoid morphology) and the paired CLL/pPL case. The percentage of prolymphocytes of each of the CLL/PL samples is indicated. (C) Heat map of the differentially methylated CpGs between B-PLL and MCL P/B (n = 10 922). (D) PCA of the differentially methylated CpGs between B-PLL and C1 MCL with classic morphology (n = 8809) including in the plot the C1 MCL P/B.