Differential DNA methylation patterns of B-PLL compared with CLL, MCL, and SMZL. (A) Number of samples with DNA methylation data available. (B) Boxplots of the first 8 PCAs including B-PLL, CLL, MCL, and SMZL cases. At bottom, the table shows the false discovery rate (FDR)–corrected P values of Wilcoxon test of pair-wise comparisons across entities. On the right, the bars represent the total percentage of the variability showing significant differences for each PCA comparison. (C) Heat maps of the differentially methylated CpGs between B-PLL and CLL (n = 5058), B-PLL and MCL (n = 2755), and B-PLL and SMZL (n = 60 841). In the case of SMZL, the top 10 000 CpGs with the highest standard deviation are represented. (D) Heat map of the 31 simultaneous differentially methylated CpGs comparing B-PLL to CLL, MCL, and SMZL. FDR levels of significance: FDR < 0.001 = ∗∗∗, FDR < 0.01 = ∗∗, and FDR < 0.05 = ∗.