Figure 5.
RT-induced activation of the cGAS/STING pathway promotes IFN type I gene and chemokine expression upregulation in A20 tumor cells. (A-D) Expression of ifna1, ifnb1, ccl5, and cxcl9 after 24, 48, and 72 hours of RT in vitro. (E-F) Expression of ifna1, inb1, cxcl9, and cxcl11 48 hours post in vivo RT. (G) Activation of STING pathway in A20 tumors treated with CART-19 alone or combination of CART-19 and RT. Graphs show the mean ± SEM. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001. b-TUB, b-tubulin; RT, Radiation Therapy; p-IRF3, phosphorylated-Interferon Regulatory Factor 3; p-STING, phosphorylated-Stimulator of interferon genes; p-TBK1, phosphorylated-TANK-binding kinase 1.

RT-induced activation of the cGAS/STING pathway promotes IFN type I gene and chemokine expression upregulation in A20 tumor cells. (A-D) Expression of ifna1, ifnb1, ccl5, and cxcl9 after 24, 48, and 72 hours of RT in vitro. (E-F) Expression of ifna1, inb1, cxcl9, and cxcl11 48 hours post in vivo RT. (G) Activation of STING pathway in A20 tumors treated with CART-19 alone or combination of CART-19 and RT. Graphs show the mean ± SEM. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001. b-TUB, b-tubulin; RT, Radiation Therapy; p-IRF3, phosphorylated-Interferon Regulatory Factor 3; p-STING, phosphorylated-Stimulator of interferon genes; p-TBK1, phosphorylated-TANK-binding kinase 1.

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