Relationship between COO and probabilistic genetic subtypes as proposed by Schmitz et al,²⁴Chapuy et al,²⁵Lacy et al²⁷(adapted from Wright et al²⁶and de Leval et al⁵⁰). Major genetic aberrations and prognosis are also shown. The width of the arrows and the solid color of the boxes correspond to the strength of the correlation between COO and molecular subtype. For example, the MCD/C5/MYD88 subtypes are assigned purely to the ABC group, whereas EZB/C3/BCL2 belongs almost exclusively to GCB subtypes. The molecular subtypes shown in boxes with color gradients include lymphomas originating from different COO groups. Notably, 37% of lymphomas cannot be assigned with sufficient probability to any of the molecular subtypes, as shown in the far-right panel. There is also a small subgroup of tumors called the composite group, presenting genetic aberrations characteristic of >1 molecular subtype (not shown in the figure). Taxonomy/abbreviations of the genetic subtypes are described in the cited original publications.