Risk factors for ischemic stroke (A) and intracerebral hemorrhage (B) among California patients with SCD from 1991 to 2019. This figure illustrates the risk factors associated with ischemic stroke and intracranial hemorrhage (ICH), accounting for the competing risk of death among California patients with SCD between 1991 and 2019. Cox regression models with correction for the competing risk of death was adjusted for sex, age at entry into the cohort, year of entry into the cohort, and Black race. All variables, except frequent hospitalizations, were included as time-dependent covariates. Frequent hospitalizations was defined as an average of ≥3 admissions per year. Previous cerebrovascular disorder includes cerebral atherosclerosis, hypertensive encephalopathy, and other ill-defined or unspecified cerebrovascular disease.