Predicted rates of first CVE type per 100 000 PY by age category and time period among California patients with SCD between 1991 and 2019. Shown are the rates of ischemic strokes (A), ICH (B), and TIAs (C). Rates were compared between each time period by age categories. Unadjusted P values are presented; no Bonferroni multiple-comparison correction was implemented.