Figure 4.
Pathologic features of histiocytic neoplasms with CLTC::SYK fusions. Photomicrographs of H&E-, CD163-, CD14-, PU.1-, or CD4-stained slides. Numbers indicate cases. Depicted are the dense histiocytic lesion with interspersed eosinophilic granulocytes in case 2, and histiocytic cells in between hyalinized collagen in case 8. In addition, the storiform-like histologic patterns in cases 9 and 11 are shown, as well as the histiocytes dissecting through the musculature that were observed in these cases. The inlets demonstrate that the cells stained positive for CD163 and had variable nuclear contours. The images of cases 10 and 12 depict dense populations of cells with xanthomatized eosinophilic cytoplasm, as well as collections of foamy histiocytes. As illustrated by photomicrographs of the tumor of case 2, histiocytes stained positive for CD163, CD14, and PU.1, whereas CD4 was more weakly positive.

Pathologic features of histiocytic neoplasms with CLTC::SYK fusions. Photomicrographs of H&E-, CD163-, CD14-, PU.1-, or CD4-stained slides. Numbers indicate cases. Depicted are the dense histiocytic lesion with interspersed eosinophilic granulocytes in case 2, and histiocytic cells in between hyalinized collagen in case 8. In addition, the storiform-like histologic patterns in cases 9 and 11 are shown, as well as the histiocytes dissecting through the musculature that were observed in these cases. The inlets demonstrate that the cells stained positive for CD163 and had variable nuclear contours. The images of cases 10 and 12 depict dense populations of cells with xanthomatized eosinophilic cytoplasm, as well as collections of foamy histiocytes. As illustrated by photomicrographs of the tumor of case 2, histiocytes stained positive for CD163, CD14, and PU.1, whereas CD4 was more weakly positive.

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