Figure 2.
Clinical correlations with CH. (A) CH frequency (at minimum VAF of 0.5%) relative to age ranges in 207 patients with TBD (red curve) and 140 age-matched healthy donors (HDs; blue curve) screened using the same panel. CH frequency in TBDs at any age range was higher than that in HD (age 0-20 years, 22% vs 0 [P = .0359]; 21-40 years, 44% vs 4% [P = .0001]; 41-70 years, 55% vs 16% [P < .001]; >70 years, 75% vs 42% [P = .31]). (B) Kaplan-Meier curves of cumulative survival probabilities relative to the entire TBD cohort (n = 207; black curve) and disease inheritance (unknown inheritance mode [blue curve], AD-TINF2; [green curve], AD non-TINF2 [red curve], and recessive or X-linked recessive [AR/XLR; pink curve]). Survival probabilities were analyzed from patient’s date of birth. The log-rank test was used to determine statistical significance (P < .05). (C) Kaplan-Meier curves of cumulative survival probabilities based on CH types. Survival probabilities were calculated from the time of the first visit. Patients who underwent hematopoietic cell transplant (HCT) were censored at the date of transplant. The log-rank test was used to determine statistical significance (P < .05). (D) Multivariate Cox proportional hazards regression for OS. Variables selected by the stepwise model are shown on the right. (E) Cumulative incidence of MDS/AML in the entire cohort based on patient age (left) and the germ line mutated gene (right). Time to MDS/AML development was calculated from the time of the first visit. (F) Kaplan-Meier curves of cumulative incidence of MDS/AML in the entire cohort based on the CH types. Survival probabilities were calculated from the time of the first visit. Patients who underwent HCT were censored at the date of transplant. The log-rank test was used to determine statistical significance (P < .05). (G) Risk of MDS/AML development determined by multivariate stepwise Cox proportional hazards regression. Variables selected by the model are shown in the figure. (H) Association between CH and solid cancer development determined by multivariate logistic regression. ALC, absolute lymphocyte count; ANC, absolute neutrophil count; Hb, hemoglobin.

Clinical correlations with CH. (A) CH frequency (at minimum VAF of 0.5%) relative to age ranges in 207 patients with TBD (red curve) and 140 age-matched healthy donors (HDs; blue curve) screened using the same panel. CH frequency in TBDs at any age range was higher than that in HD (age 0-20 years, 22% vs 0 [P = .0359]; 21-40 years, 44% vs 4% [P = .0001]; 41-70 years, 55% vs 16% [P < .001]; >70 years, 75% vs 42% [P = .31]). (B) Kaplan-Meier curves of cumulative survival probabilities relative to the entire TBD cohort (n = 207; black curve) and disease inheritance (unknown inheritance mode [blue curve], AD-TINF2; [green curve], AD non-TINF2 [red curve], and recessive or X-linked recessive [AR/XLR; pink curve]). Survival probabilities were analyzed from patient’s date of birth. The log-rank test was used to determine statistical significance (P < .05). (C) Kaplan-Meier curves of cumulative survival probabilities based on CH types. Survival probabilities were calculated from the time of the first visit. Patients who underwent hematopoietic cell transplant (HCT) were censored at the date of transplant. The log-rank test was used to determine statistical significance (P < .05). (D) Multivariate Cox proportional hazards regression for OS. Variables selected by the stepwise model are shown on the right. (E) Cumulative incidence of MDS/AML in the entire cohort based on patient age (left) and the germ line mutated gene (right). Time to MDS/AML development was calculated from the time of the first visit. (F) Kaplan-Meier curves of cumulative incidence of MDS/AML in the entire cohort based on the CH types. Survival probabilities were calculated from the time of the first visit. Patients who underwent HCT were censored at the date of transplant. The log-rank test was used to determine statistical significance (P < .05). (G) Risk of MDS/AML development determined by multivariate stepwise Cox proportional hazards regression. Variables selected by the model are shown in the figure. (H) Association between CH and solid cancer development determined by multivariate logistic regression. ALC, absolute lymphocyte count; ANC, absolute neutrophil count; Hb, hemoglobin.

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