Graphic representation of remedial strategies after delayed or missed dose of DOACs administered once daily. Strategy A, omit the missed dose and consume the next regular dose at the appointed time; strategy B, consume the regular dose immediately and omit the missed dose at the next appointed time; strategy C, consume the regular dose immediately and take a regular dose at the next appointed time; strategy D, consume the regular dose immediately and take a remedial dose at the next appointed time; strategy E, consume a remedial dose immediately and take a regular dose at the next appointed time; strategy F, consume the regular dose plus a remedial dose immediately and omit the next appointed dose; and strategy G, omit the missed dose and consume the regular dose plus a remedial dose at the next appointed time.