Comparison to LCH,²⁴ IDCH differs in its mutational profile. IDCH showed significant enrichment in KRAS and NRAS mutations, which are extremely rare in LCH. Although both diseases have frequent BRAF^V600E mutations, IDCH appears to have concurrent mutations in myeloid neoplasm–associated genes such as TET2, DNMT3A, and ASXL1, unlike LCH.