Up-front AYA B-ALL treatment schemas. Ara-C, cytarabine; CNS3, central nervous system; CPM, cyclophosphamide; cXRT, cranial radiation; DEX, dexamethasone; DNR, daunorubicin; DOX, doxorubicin; HD-MTX, high-dose methotrexate; IT-MTX, intrathecal methotrexate; IT-Arac, intrathecal cytarabine; PEG, pegaspargase; PO-MTX, oral methotrexate; Pred, prednisone; 6-MP, mercaptopurine; 6-TG, thioguanine; VCR, vincristine.