OS. OS (of N = 357) is stratified by (A) CCMUS; (B) Hb <10 vs ≥10 g/dL; (C) having ≥2 mutations; (D) having a signaling pathway mutation; (E) multivariable analysis including the variables of Hb <10 g/dL and having a signaling pathway mutation (solid lines indicate having a signaling pathway mutation, dotted lines indicate not having a signaling pathway mutation, blue indicates Hb ≥10 g/dL, and red indicates Hb <10 g/dL); and (F) multivariable analysis including the variables of Hb <10 g/dL and ≥2 mutations (solid lines indicate having ≥2 mutations, dotted lines indicate having <2 mutations, blue indicates Hb ≥10 g/dL, and red indicates Hb <10 g/dL).