Schematics of the NG2-centered regulatory network in MLLr B-ALL. (A) The MLL fusion protein binds to MLL-specific hypomethylated regulatory elements at the NG2 locus, driving MLL-specific NG2 activation in MLLr B-ALL. (B) NG2 interacts with FLT3 on the cell surface, triggering a ligand-independent FLT3 signaling cascade and inducing AP1-mediated inhibition of the GR and its downstream pathways. (C) The NG2-FLT3 interaction site may offer a new target for drug development to improve treatment efficacy for patients with MLLr B-ALL. TES, transcription end site; TSS, transcription start site. The figure was prepared by Yan Zhao.