Fibrin network structure and its correlations with peak plasmin in patients with BDUC (n = 6) and HCs (n = 9). (A) Fibrin network structure of a representative patient with BDUC and an HC. The clot structure was analyzed using confocal microscopy (Zeiss LSM700) with a 63×/1.4 oil immersion objective. The settings included a pinhole aperture of 1 Airy unit (0.7 μm section), an image/frame size of 101.5 μm × 101.5 μm at a resolution of 1024 × 1024 pixels, and a pixel size of 0.1 μm. (B) Comparison of the fibrinogen levels, fiber density, and fiber diameters and the association of fiber density and diameter with the peak plasmin level in 6 representative patients with BDUC and 9 HCs. The 2 representative participants showed in panel A are marked as light red (BDUC) and light blue (HC). Significance is indicated as follows: ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001; ns, not significant.