PG parameters in patients with BDUC and HCs. Procoagulant activity was initiated by the addition of exogenous TF (PPP-reagent LOW, ∼1pM TF, Diagnostica Stago) to recalcified plasma, and PG was triggered by the addition of exogenous tPA (0.62 μg/mL). PG was detected via fluorogenic substrate cleavage over time. Black lines represent the median and IQR. Significance (adjusted for age, sex, blood group O, and fibrinogen levels) is indicated as follows: ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001.