OS. (A) OS according to Ven-Obi (blue) and Clb-Obi (red) arm. (B) OS according to presence (solid line) or absence (dashed line) of TP53 deletion/mutation. (C) OS according to mutated- (solid line) or unmutated- (dashed line) IGHV status. (D) Multivariable models for OS for the Ven-Obi (upper panel) and Clb-Obi arm (lower panel). ECOG, Eastern Cooperative Oncology Group. mIGHV, mutated IGHV; uIGHV unmutated IGHV; del/mut, deletion and/or mutation.